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KMID : 0361020000430080854
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 8 p.854 ~ p.861
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Expression of Vascular Endothelial Growth Factor and Platelet-Derived Endothelial Cell Growth Factor in Head and Neck Squamous Cell Carcinoma an It’s Relation to Angiogenesis
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Choi Hee-Suck
Kim Yong-Bum
Song Young-Ho
Hong Nam-Pyo
An Hwoe-Young
Kim Youn-Hwa
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Abstract
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Background and Objectives: Tumor angiogenesis is an essential process required for growth and metastasis in cancer. Vascular endothelial growth factor(VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) are known to be angiogenetic factors. The objectives of this study were to measure the expression of VEGF, PD-ECGF and microvessel density (MVD) in head and neck squamous cell carcinoma (HNSCC) and compare them to normal larynx. We also evaluated relationships of VEGE, PD-ECGF and MVD to clinicopathologic findings in HNSCC.
Material and Methods: The expression of VEGE, PD-ECGF and MVD were evaluated by immunohistochemical staining of 26 cases of HNSCC and 6 cases of normal larynx.
Results: The expressions of VEGE, PD-ECGF and MVD in HNSCC were significantly higher than in the normal control (p<0.05). MVD were significantly correlated with VEGE and PD-ECGF expressions in HNSCC (p<0.05). The VEGF, PD-ECGF expression and MVD correlated with many clinicopathologic finding s in HNSCC.
Conclusion: These results suggest that VEGF and PD-ECGF are involved in angiogenesis and are related to clinicopathologic finding of HNSCC. Furthermore, we propose that expressions of VEGF, PD-ECGF and MVD to be investigated more in the future a prognostic indicators of HNSCC. (Korean J Oolaryngol 2000:43:854-61)
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KEYWORD
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VEGF, PD-ECGF, Vascular endothelial growth factor, Platelet derived endothelial cell growth factor, Angiogenesis, Head and neck squamous cell carcinoma
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